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Aging Cell 20 , e13328 (2021)

Except for emergency therapy, do not use in animals with chronic nephritis and hyper-corticalism (Cushings syndrome)

Fat tissue contains aromatase, an enzyme that converts testosterone into estrogen

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Clinical bottom line for GLP-1 agonists in PCOS Clearly benefits: Women with PCOS and insulin resistance and/or overweight/obesity specifically for improving cycle regularity, reducing hyperandrogenism, supporting sustained weight loss, and reducing long-term cardiometabolic risk