While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)
Do not self-administer unless specifically instructed and trained by a healthcare provider
Elevated serum B12 levels may sometimes indicate underlying medical conditions rather than true overdose, warranting clinical investigation to exclude haematological disorders, liver disease, or renal impairment
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Your doctor may test for anemia (low iron levels) by running a panel for red blood cells, hemoglobin, hematocrit, and iron levels, and all of them may come up normal
