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Based on the aforementioned effects and mechanisms of 5-ASA, we employed 5-ASA as the positive control drug in our in vivo experiments

To date, available clinical experience primarily derived from populations with T2DM or obesity receiving concomitant immunomodulatory therapies has not revealed major safety signals related to increased infection risk or immune suppression

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Collectively, these results indicate that through the elimination of oxidative stress, extracellular signalregulated kinase activation, and ER stress, l-Carnitine reduced cell autophagy/apoptosis and concomitantly increased cell viability in RTCs

doi: 10.1038/nm.3128 92 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

Svensson is a co-founder of Merrifield Therapeutics.