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they can be profoundly debilitating, requiring extensive medical intervention and causing significant long-term health issues

Gonda X, Dome P, Serafini G, Pompili M

Bioavailability is lower than injectable semaglutide, which is why the oral doses are much higher

These doctors are often more familiar with the current evidence base than a general GP who sees weight management as a small part of their practice

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However, for patients with pre-existing gastrointestinal conditions such as gastroparesis (paralyzed stomach), severe gastroesophageal reflux disease (GERD), or inflammatory bowel disease (IBD), this mechanism can exacerbate symptoms