La reduccin del estrs oxidativo mitocondrial tiene implicaciones amplias para la funcin celular, ya que el dao oxidativo a protenas mitocondriales, lpidos y DNA mitocondrial puede comprometer la produccin de ATP, iniciar vas de apoptosis, y contribuir al envejecimiento celular
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Rethinking the Approach: Small Molecules Enter the Scene (2016-2020) Even as Novo Nordisk pursued the SNAC-semaglutide approach, a parallel and more radical strategy was taking shape in laboratories in Japan and the United States
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The accumulation of the results of these ongoing cardiovascular outcome trials should be able to answer questions about cardiovascular benefits of GLP-1 RAs that were strongly suggested by previous preclinical and clinical studies and their possibility to lower the excessive cardiovascular burden in patients with T2D
