Additionally, attention should also be paid to off-target effects of ferroptosis induction (92)
Clinical studies have shown that it has several antiaging and cardio- and neuro-protective properties, and can also alleviate osteoarticular, urologic, and menopause-related discomfort.60 The extract has also been found to have a photoprotective, modulating effect on skin pigmentation.61 Several RCTs evaluating the use of French maritime pine bark extract have shown a significant reduction in signs of facial aging, such as wrinkles and solar lentigines,62,63 and increased levels of hyaluronan synthase and type I collagen.64 Another RCT (n=76) showed increased skin elasticity and hydration and decreased skin darkening in Asians working in highly polluted areas after treatment for 12 weeks.65 No relevant adverse effects were reported
Their clinical impact has since expanded dramatically due to their ability to induce sustained weight loss, improve insulin sensitivity, reduce systemic inflammation, and alter gut physiology
Expertly crafted
Schjoedt KJ, Rossing K, Juhl TR et al (2006) Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
Ozempic is just one brand-name version of semaglutide, a medication prescribed to treat type 2 diabetes
