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Off-label use of semaglutides continued to grow in 2022 for those with employer-sponsored insurance

It plays a crucial role in maintaining bone health, regulating immunity, protecting cardiovascular function, and inhibiting tumor growth (Powaa et al., 2024)

Abnormal (dysbiotic) gut microbiota could account for leaky gut and inflammation in older adults (3, 9), since dysbiotic microbiota can produce metabolites that interact with the hosts intestinal epithelial cells to reduce epithelial barrier proteins like zonulin-1 ( Zo1 ), occludin ( Ocln ), and claudins, resulting in disrupted cell-to-cell connections, which compromises intestinal permeability (10, 11)

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When prescribed for FDA-approved uses, many patients can get insurance coverage for weight loss drugs

Compounded oral semaglutide is not FDA-approved as a branded medication, but it is manufactured by licensed 503A compounding pharmacies