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More importantly, resolvin given as late as 12 h after APAP was still protective, which means it extends the therapeutic window eight-fold compared to the standard antidote NAC [92]

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Micronized progesterone has been associated with improved sleep architecture and reductions in nighttime awakenings [21], an effect that appears to involve its interaction with GABA receptors in the brain, the same receptor system targeted by many sedative medications, but through a gentler and more physiologically integrated mechanism