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A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

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Glycine 1228 is the sole residue responsible for the stimulation of GSH transport and associated collateral sensitivity in TM16-TM17 To characterize the effect of the original replacement within the nine identified clusters of chimera M8, we first verified that all the mutants were well expressed and addressed to the plasma membrane (Supplementary Fig