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Neuroimaging studies show semaglutide reduces start of brain reward centers in response to food cues, decreases food cravings, and enhances satiety signals

The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea

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Despite these promising findings, current evidence is preliminary, and the mechanistic basis for any comparative or synergistic advantages remains speculative