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PMCID: PMC3296184

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Both monogenic defects [160, 161] and polygenic cumulative effects [162, 163] have been demonstrated to constitute the genetic basis of disease pathogenesis, with this susceptibility being influenced by ethnicity-specific [164] and age-specific [165, 166] variations as well as epigenetic regulatory mechanisms [167, 168]

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Animal studies report effects on inflammatory markers in models of gastric ulcers, inflammatory bowel conditions, and various organ injuries

It also aids in lipogenesis in adipose tissue, stimulates endothelial cell proliferation, and offers protection against cardiovascular and cerebrovascular diseases