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Improves insulin sensitivity and helps regulate blood glucose levels
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Additionally, the FDA label for tirzepatide (Mounjaro, Zepbound) specifically warns that it may decrease the absorption of oral contraceptives, recommending backup contraception during initiation and dose escalation
The data suggests retatrutide's triple-agonist mechanism already delivers substantially greater effects than semaglutide alone further supporting the argument that adding semaglutide to retatrutide is pharmacologically redundant
Funding This work was supported by grants from the Natural Science Foundation of Guangdong Province (2018A030313846 and 2021A1515012593), the Science and Technology Planning Project of Guangdong Province (2019A030317020), the National Natural Science Foundation of China (81802257, 81871859, 81772457, 82172750, 82172811, and 82260546), the Guangdong Basic and Applied Basic Research Foundation (GuangdongGuangzhou Joint Funds) (2022A1515111212), and the Science and Technology Program of Guangzhou (2023A04J1257)
