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A study investigating the effect of metal-NPs on bacterial cells showed a positive correlation between membrane permeability and increased cytoplasmic leakage, reduced total ATP levels and ATPase activity [193]

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Furthermore, a third melatonin-binding site (MT3) has been characterized and identified as the cytosolic enzyme quinone reductase 2 (QR2), a known detoxifying enzyme that reduces menadione and other quinones 26,27

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