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They work by mimicking the action of specific hormones that regulate appetite

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In the semaglutide arm, risk fell by about 4% per 5 kg lower baseline weight (HR 0.96), whereas this trend was not significant in the placebo arm

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GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

The use of scRNA-seq has revealed previously unrecognized heterogeneity among -cells and their differentiated responses to metabolic and inflammatory signals