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In TMAO-treated macrophages, significant upregulation is observed in both M1 signature cytokines (including IL-1, IL-6, TNF-, Chemokine (C-X-C motif) ligand (CXCL) 9, and CXCL10) and key genes such as NLRP3 (77)

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Consistent adherence to the prescribed dosing schedule is also necessary for achieving the full benefits of the medication, with Semaglutide GLP-1 intended for long-term use in managing obesity as a chronic condition

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