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The associations between glutathione, chronic disease, and environmental pollutants appear to be of extraordinary significance, and yet often go unrecognized

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Moreover, Gln is an essential substrate for the immune system, and prolonged use of Gln metabolic inhibitors might weaken the anti-tumor immune response ( 2 The role of Gln metabolism in tumor Emerging evidence shows that Gln metabolism is involved in tumor progression in two specific ways ( Figure 1 )

M1-M secretes a variety of inflammatory cytokines such as IL-6 or IL-1, and are involved in inflammation and pathogens clearance

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Most ISRs were mild