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NAD+ is a vital coenzyme that plays a key role in cellular energy production and metabolism

Moreover the lack of TNFR2 (selective ablation of TNFR2) in astrocytes resulted in changed expression of key proteins involved in hippocampal synaptic transmission and plasticity, increased hippocampal gliosis, impaired LTP, and deficits in learning and memory in males as compared to females [84]

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Exploring plasma metabolomic changes in sepsis: a clinical matching study based on gas chromatography-mass spectrometry