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Conditions that drastically alter the gut microbiome, such as inflammatory bowel disease, are associated with very high levels of homocysteine

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This makes it ideal for managing chronic inflammatory conditions like rheumatoid arthritis or osteoarthritis, where sustained pain relief is needed throughout the day

Several weight-independent mechanisms may contribute to the cardioprotective effects of GLP-1RAs, including direct vascular and myocardial effects [29], improved plaque stability [29], anti-inflammatory benefits [30], and modulation of prothrombotic [31] and neurohormonal activity [15]

Endocr Rev 33(6):9811030