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Regulating melanocytes

Cytokines and chemokines secreted by leukocytes, such as tumor necrosis factor, IL-6, and granulocyte colony-stimulating factors to name a few activate endothelial cells, stimulate neovascularization and leukocyte migration, and cause expansion of synovial fibroblast-like and macrophage-like cells [68]

J Diabetes Complications 1999;13:251-3

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A major difficulty in determining if SGLT2 inhibitors actually increase the risk of FG is that FG is very rare making definitive studies difficult

An example of such a compound is OR10141