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This rapid turnover makes it unlikely that peripheral GLP-1 significantly contributes to endogenous activation of central GLP-1Rs

Uno studio dellUniversit di Oxford pubblicato sul BMJ che ha analizzato i dati di oltre 9.000 pazienti da 37 studi clinici ha stimato che i benefici cardiometabolici scompaiono in media entro circa 18 mesi dalla sospensione senza interventi di mantenimento

Transl Psychiatry 5:e583e583 Tetelbaun L, Mullally JA, Frishman WH (2024) The first triple agonist for antiobesity: Retatrutide

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Since LH is the direct signal that tells the Leydig cells in the testes to produce testosterone, less LH means less testosterone production