Qutayba Almerie, MD, MSc, FRCS Consultant Upper GI & Bariatric Surgeon, Medical Director at Phoenix Health.
This is the single most important point for dose-selection decisions going forward and is the reason the 9 mg arm and the new 4 mg maintenance dose are under such close scrutiny
For this review, we evaluated recommendations from the Japanese Circulation Society / Japanese Heart Failure Society (JCS/JHFS 2025), American Heart Association (AHA 2022), and European Society of Cardiology (ESC 2021/2023), as these represent widely cited, contemporary international guidelines that incorporate the most up-to-date clinical trial evidence and offer complementary perspectives across different healthcare systems
166 , 199207.e115 (2013)
These are most frequently associated with dose escalation periods
The pricing felt reasonable compared to other programs I looked into, and nothing felt pushy or rushed