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The heavy hand of regulation didnt come out of nowhere

Predictors of weight loss after bariatric surgerya cross-disciplinary approach combining physiological, social, and psychological measures

Most experimental groups from all three datasets integrated well, however, neurons from mice treated once daily with semaglutide in the Ludwig 54 dataset did not integrate well, suggesting that longer-term administration of GLP-1R agonists continue to have a large impact on DVC neuron cell state after the initial dose, although this difference may be confounded by the reduction in body weight (Extended Data Fig

Glucagon promotes hepatic fatty acid oxidation (fat burning in the liver) and reduces intrahepatic lipid accumulation, which is particularly beneficial for MASH/NAFLD

The main safety concern isnt the GLP-1 itself

The identified mechanisms include: Competitive Reuptake Inhibition: Amphetamine enters the presynaptic neuron either by passive diffusion or by acting as a competitive substrate for the plasma membrane monoamine transporters