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The NIH Office of Dietary Supplements identifies post-bariatric surgery patients as a group requiring monitoring and potentially injectable supplementation

"Obesity is prevalent across every socioeconomic status in America

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Patients with higher starting weights often see faster absolute pound losses in early weeks, while those closer to goal weight may experience more gradual changes

PL7737 has comparable potency to small molecule agonists (MK-0493, bivamelagon) that were inefficacious in general obese populations and RM-718 is less potent on MC3R and MC4R than setmelanotide, raising concerns for potential lack of efficacy in future general obesity trials

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