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9-11 If a GLP-1 RA is determined to be the best option for the patient, pharmacists and providers should consider the following recommendations: Follow dosing recommendations as directed by the manufacturer

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In an in vitro study, tirzepatide elicited a cAMP response in a human pancreatic -cell line that was significantly higher than that observed for either GLP-1 or GIP alone, indicating a synergistic or additive activation of signaling in pancreatic -cells by GIP and GLP-1 (63)

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