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Compounded GLP-1s: Pharmacy-prepared versions that aren't FDA-reviewed for safety, efficacy, or quality, so it's important to confirm clinician oversight, state licensure, and pharmacy sourcing before choosing this option

Zepbound through Ro (FDA-approved) or Noom GLP-1Rx Plus (compounded tirzepatide) Want the gentlest entry with lowest side-effect risk

A clinically significant interaction exists between tirzepatide and oral contraceptives, with FDA labeling advising use of non-oral or backup contraception for 4 weeks after initiation and each dose increase

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Proper storage of semaglutide is essential for maintaining medication potency throughout its labeled shelf life