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PASC could encompass several adverse clinical impairments that may trigger chronic metabolic dysfunctions involving cardiovascular (CV), central/peripheral nervous (CNS/PNS), gastrointestinal (GI), pulmonary, reproductive, skeleto-muscular, and endocrinal systems 6,7

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The brain is particularly susceptible to oxidative stress due to its high oxygen consumption, lipid content, and relatively low levels of antioxidant enzymes compared to other tissues

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Most commercially significant generic challenges use Paragraph IV