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With Transcend, Lilly had a full picture of data, to the point that they published the data in The Lancet, but the trial was only 40 weeks long and multiple endpoints including A1c, weight loss and other markers havent quite hit the full potential of the drug for diabetics so were left with questions on what happens when you take it for a longer term

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Kynurenine is metabolized in astrocytes and microglia to quinolinic acid (QUIN, an NMDA receptor agonist with neurotoxic properties) or kynurenic acid (KYNA, a neuroprotective metabolite)

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