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It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate

Hematological parameters, including red blood cell count (RBCs), hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), total white blood cell count (WBCs), and the differential WBC count (neutrophils, lymphocytes, monocytes, eosinophils, and basophils), were analyzed using a Mispa Count Plus 5-part differential hematology analyzer

Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease

For this reason, these medications are often used in people with type 2 diabetes who also have heart or kidney problems

Hsu et al., 2019)

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