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Ultrastructural pathology and restoration in PFC and hippocampal CA1 neurons Transmission electron microscopy (TEM) analysis of prefrontal cortex (PFC) and hippocampal CA1 neurons revealed significant ultrastructural alterations across experimental groups

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Although the pathogenic mechanisms by which these factors lead to SGN damage are various, researches have documented that the oxidative stress is a basic mechanism involved in SGNs death (Xiong et al., 2011