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274 A subsequent phase III clinical trial (NCT06183931) will assess its efficacy on the basis of all-cause mortality and cardiovascular events

Treatment typically begins with 0.25 mg once weekly for 4 weeks as an initiation dose only (not for glycaemic control)

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To fully understand the role of GLP-1RAs in managing diabetes and depression, further randomized controlled trials and long-term studies are needed, Guo added