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Patience during escalation is critical

But retatrutide may be even more effective , for several reasons: Glucagon receptor activation promotes hepatic fat oxidation Reduces liver fat accumulation more robustly Improves liver enzyme levels (ALT, AST) In a subgroup analysis of the retatrutide Phase 2 trial: Patients with suspected NAFLD showed a 70%+ reduction in liver fat content , measured by MRI-PDFF These effects surpassed the reductions seen with tirzepatide and semaglutide in comparable studies Another study showed that 93% of patients on the highest dose of retatrutide had 100% resolution of fatty liver

Diabetes Care 32 , 8490 (2009)

It's hard to lose weight when you're over 60 but it is possible

But in most cases, the medication itself is not the direct cause

The question is whether we build the practice around it