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GLP-1 activates the GLP-1 receptor (GLP-1R) in a glucose-dependent manner to potentiate insulin release and suppress glucagon secretion, and thereby lead to blood sugar lowering and weight loss [3][4]
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The Shanghai Osteoarthritis Cohort study found lower rates of knee surgery among GLP-1 users 39
The Bigger Picture: Side Effects in Context Side effects that are real, common, and sometimes disruptive need to be weighed against what these medications can genuinely offer for the right patients
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