Mounjaro (tirzepatide) is FDA-approved for type 2 diabetes in adults and children aged 10 years and older to help improve blood sugar (glucose) levels, used alongside diet and exercise
Roughly 30% of participants achieved their weight loss target of 20% or more
Improved Blood Pressure and Lipid Profiles Weight loss and direct metabolic effects from GLP1 contribute to reductions in both systolic and diastolic blood pressure, as well as improvements in LDL cholesterol and triglycerides
For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable
Cardiovasc Res 2024: ivabradine, a funny-current (HCN/I_f) blocker, does not abolish the effect, which places the chronotropy on the SR calcium clock rather than the funny channel
Avoid applying strong vitamin C products, high-concentration retinoids, or low-pH chemical exfoliants at the same time as AHK-Cu