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Marston in the Eastern District of Pennsylvania, consolidates claims that GLP-1 drugs caused NAION non-arteritic anterior ischemic optic neuropathy, a sudden, painless form of vision loss sometimes called "eye stroke." A July 2024 study in JAMA Ophthalmology found that semaglutide users faced a 4.28x increased risk of NAION among diabetics and a 7.64x increased risk among weight-loss patients

The present study demonstrated that switching to oral semaglutide from DPP-4 inhibitors enabled more participants to achieve HbA1c values below 7%

Associated datasets are provided in Supplementary Tables 14 and 67

The genetic variable underneath every GLP-1 decision Whichever compound a patient and provider choose, the upstream genetic architecture is shared

But Eli Lilly seems to be aware of that, given its added focus on people with severe obesity and weight-related health problems like knee osteoarthritis