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Timing and Administration Alpha-lipoic acid should ideally be taken on an empty stomach at least 30 minutes before a meal or at least 2 hours after a meal because food reduces bioavailability by approximately 25% [1][5]

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Endurance athletes may also deplete B12 stores faster due to increased metabolic demands and potential gastrointestinal stress from long training sessions

The mechanism might be related to its own antioxidant properties and GSH activating effect

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