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The CSF levels of corticosterone (Plhagen et al., 2010) and neuroactive steroids such as allopregnanolone (THP) and 5 -dihydroprogesterone (DHP) (di Michele et al., 2003) have been found to be decreased in PD

Therefore, future research is needed to further validate acylcarnitines and BAs as clinical biomarkers of APAP toxicity

CDC summarizes USP guidance: date an opened multi-dose vial at first puncture and discard it within 28 days unless the manufacturer states another opened-vial date. The dose count and 28-day window together require three vials for the 12-week protocol

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