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Ozempic (Semaglutide) is a Food and Drug Administration (FDA)-approved medication used to manage Type 2 diabetes and lower the risk of major cardiovascular (heart) events like heart attack, stroke, or death in individuals with both Type 2 diabetes and cardiovascular disease
The approval validated years of preclinical research and opened the door for subsequent generations of GLP-1 drugs with improved efficacy and convenience profiles
GLP-1 receptors are expressed throughout reward-related brain regions: the ventral tegmental area, nucleus accumbens, and lateral septum
IGF1R is a receptor tyrosine kinase, meaning ligand binding triggers autophosphorylation and downstream signaling cascade activation
Common Side Effects: Mild stomach discomfort Temporary nausea or bloating Slight headache Mild taste changes after intake Serious & Rare Side Effects: Allergic reactions (rash, itching) Severe gastrointestinal discomfort Breathing difficulty (very rare) Most side effects are mild and temporary, but discontinue use if unusual symptoms persist
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