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The decreased levels of LAC in subjects with MDD are linked to shorter leukocyte telomere length (LTL), increased body mass index (BMI), and higher reported rates of childhood trauma and are predictive of lack of antidepressant responses as assessed using the Hamilton depression rating scale-21

Indeed, the inhibition of complex 1 was observed in many cancer cells (Table 1) and usually leads to reduced mitochondrial OXPHOS and ATP depletion, ultimately resulting in AMPK-mediated activation of catabolic pathways and inhibition of anabolic processes through its regulation of mechanistic target of rapamycin complex 1 (mTORC1) (54)