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J Cell Biol 216:463476 Dixon DP, Cummins I, Cole DJ, Edwards R (1998) Glutathione-mediated detoxification systems in plants
Excess glucocorticoid exposure suppresses GH secretion mainly through the increase in hypothalamic somatostatin tone, whereas low cortisol levels causes relative GHD that is reversible by glucocorticoid therapy (Giustinas effect) ( Figure 5 ) (104)
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In the GCH1-BH4 pathway, BH4 functions as an antioxidant capable of trapping peroxidized lipid radicals, with GCH1 serving as the rate-limiting enzyme in BH4 biosynthesis
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