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Non-metabolic progressive comorbidities such as osteoarthritis would also be expected to benefit from substantial weight loss

Glucose-dependent insulin-releasing polypeptide (GIP) and GLP-1 are both secreted in response to food ingestion and potentiate the glucose-induced insulin response (figure 1)

Rondard, P

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While both peptides stimulate growth hormone release, they differ in potency, intended use, body composition effects, and the type of results people typically pursue

At 15 mg weekly, the maximum dose produces the highest side effect rates but also the best average weight loss results (22.5%)