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We were also reassured by the absence of any signal for increased hospitalization or surgery, which are common concerns with medications that affect gastrointestinal function. If future studies confirm these results, he added, they could reassure clinicians that GLP-1 receptor agonists can be used safely in certain patients with Crohns disease who also have obesity or diabetes

Upon activation, the receptor primarily couples to the stimulatory G s , stabilized by specific contacts with residues such as R176 2.46b and Y402 7.57b (Song et al., 2017

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