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Drug class: Tirzepatide is a dual GIP receptor and GLP-1 receptor agonist
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Consequently, the development of kidney-specific antisense oligonucleotide (ASO) or adeno-associated viral (AAV) transduction methods is advantageous, as these approaches can selectively inhibit ANGPTL4 in proximal tubules, glomerular podocytes, and glomerular endothelial cells, thereby avoiding the adverse systemic effects associated with whole-body ANGPTL4 loss (Srivastava et al., 2024)
Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes
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However, additional concerns have been noted, including modest increases in heart rate observed in clinical trials and reports of dysesthesia, where normal sensations are perceived as painful, in some users
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