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Catalyzed by glutathione- S transferases , the reactive SH group of glutath-ione can form a thioether by reacting with electrophilic carbon double bonds, carbonyl groups, and other reactive groups

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IGF-1 binding to insulin-like growth factor receptors can activate downstream IRS and promote angiogenesis through the MAPK and PI3-K pathways [21, 38, 39]

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The GliSODin group had significantly lower cellular DNA damage as evidenced by a test called Comet Assay. Also, these findings coincided with reduced blood isoprostane levels, another marker of oxidative stress