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Multiple cohorts report hazard ratios in the range of 0.60.8, even after adjusting for weight loss and glycemic control [14]

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Sharma, S., Anjaneyulu, M., Kulkarni, S

In neonatal mice, linaclotide increased fluid secretion as a consequence of age-dependent elevated guanylate cyclase (GC-C) agonism, which was associated with increased mortality within the first 24 hours due to dehydration

A small area of redness, mild swelling, warmth, and itch that peaks within 24 to 72 hours and then fades, sometimes helped by simple measures like a cold compress or topical soothing creams