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[7] implicated 4-OH-E 2 in the induction of estrogen-responsive genes, a response that exhibited partial or no abrogation by coadministration with an antiestrogen, providing evidence for the ability of 4-OH-E 2 to carry out genetic upregulation via a pathway independent of ER signalling

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Once the immediate deficiency is corrected, the frequency is reduced to weekly and eventually monthly sessions

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The term clearance Clearance is a misunderstood term originally used by physiologists to calculate the net volume of blood cleared of a specific substance per unit of time by the combination of glomerular filtration, renal tubular reabsorption, and tubular secretion

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