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The OGDHc is particularly sensitive to lipoyl glutarylation, with ABHD11 inhibition impairing normal OGDHc catalysis and perturbing 2-oxoglutarate (2-OG) metabolism

Figure 1 4.1 Macrophage fatty acid metabolic disorders potentiate MSU crystal-induced inflammation Numerous studies have shown that the inflammatory factor interleukin-1 beta (IL-1) is essential for MSU crystal-driven inflammation and is released, in place of infiltrating neutrophils or monocytes, from the resident macrophages in the initial stage of GA (38, 39)

Kumar Singh et al., 2019

Given the association between ASD and gastrointestinal abnormalities, food picking, and food aversion, many individuals with ASD have concurrent deficiencies in macro and micronutrients