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In hepatocytes with HO-1 overexpression, cell viability was markedly impaired, and this effect was further exacerbated by FAC treatment

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doi:10.1073/pnas.0707258104

(More information) The tolerable upper intake level (UL) for selenium is 400 g/day for adolescents and adults and includes both selenium obtained from food, which averages about 100 g/day for adults in the US, and selenium from supplements