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In addition, we found that the downregulation of ACs metabolism-related genes and protein expression by VPA in both mouse liver and hepatocytes was dose-dependent, i.e., the greater the VPA concentration, the more pronounced the downregulation effect

Gene sets related to the MAPK and mTOR signaling pathways were retrieved from the Molecular Signatures Database (MSigDB) via the msigdbr R package

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The psychological impact of quick body changes sometimes exacerbates underlying mental health conditions

In the PCOS ovarian microenvironment, key functional cells such as granulosa cells are particularly vulnerable to this pathway, which directly impairs follicular development and maturation

Excessive NAPQI production in toxicity depletes GSH stores in the liver