Compared with originator, follow-on injectable semaglutide DSs and DPs had new impurities and impurity patterns, including high molecular weight proteins, trace metals, anions, counterions, and residual solvents
While extensive animal studies exist, human data is extremely limited and lacks rigorous clinical trials
It also strengthens muscles and speeds up the recovery of damaged muscles
For example, they still don't fully replicate the complexity of the human brain, and they may not reach full maturity, which can affect their ability to model disease processes faithfully 186
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There is insufficient data to assess whether the observed anti-exenatide antibodies in pediatric patients had an effect on the incidence or severity of hypersensitivity reactions or injection site reactions
