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However, in cases of chronic microbial dysbiosis induced by exposure to environmental toxicants, ingestion of a high-fat diet can cause changes in the GI environment that can enable distinct microbes to proliferate and infiltrate neighboring gut environments, and subsequently trigger deleterious inflammatory pathways (Figure 1) (Sun et al., 2018

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The IV and injectable timelines carry the strongest anecdotal support

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As an example, GSH depletion has been shown to promote pro-inflammatory microglial phenotypes and amplify astrocyte-microglia crosstalk (Vilhardt et al., 2017)

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